If you’ve tried everything — supplements, prescriptions, meditation — and still feel anxious, overstimulated, or unable to sleep, there might be a genetic reason.
One commonly overlooked factor is the GAD1 gene mutation, which directly impacts how your brain produces GABA (gamma-aminobutyric acid) — the neurotransmitter responsible for calm, relaxation, and sleep.
What Is the GAD1 Gene?
The GAD1 gene helps convert glutamate (a stimulating brain chemical) into GABA, the brain’s main calming chemical.
When this gene isn’t functioning efficiently, it can result in low GABA levels and excess stimulation — like having a car with a jammed gas pedal and no brakes.
Common Symptoms of Low GABA from a GAD1 Mutation
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Persistent anxiety or tension
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Racing thoughts, especially at night
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Difficulty falling or staying asleep
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Muscle tightness, jaw clenching, or irritability
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Sensitivity to lights, noise, or overstimulation
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Feeling "on edge" for no clear reason
These symptoms are often labeled as generalized anxiety or insomnia, but for many people, they're connected to how their genes handle neurotransmitter balance.
Why Genetic Testing for GAD1 Matters
Many people have no idea they carry a GAD1 mutation. They try different medications or supplements, but nothing seems to help long-term — because the underlying issue hasn’t been addressed.
Knowing whether your GAD1 gene is impacted takes the guesswork out of treatment. Once you understand how your brain makes GABA, you can create a plan that supports what your body truly needs.
How to Support GABA Production If You Have a GAD1 Mutation
If you do carry this mutation, here are some targeted strategies:
1. Use Nutrients That Support GABA:
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Magnesium glycinate or bisglycinate – a calming form of magnesium
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Vitamin B6 (P5P) – the active form needed for GABA synthesis
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L-theanine or taurine – amino acids that support relaxation and neurotransmitter balance
2. Reduce Glutamate Load:
Avoid foods and additives that increase brain stimulation:
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Monosodium glutamate (MSG)
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Aspartame
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Processed snack foods and artificial flavor enhancers
3. Regulate the Nervous System:
GABA works best when your nervous system is supported with:
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Breathwork and vagus nerve activation
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Regular movement
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Consistent sleep-wake cycles
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Reducing overstimulation from screens, noise, or chaos
How to Test for GAD1
You don’t need bloodwork or complicated labs.
At Genetic Wellness, a simple cheek-swab test can analyze your GAD1 gene and other critical genes related to mood, stress, inflammation, detoxification, and more.
This kind of testing helps personalize your care and eliminate the trial-and-error approach to managing your mental health.
Take the First Step Toward Calm
You don’t have to keep guessing why you feel anxious, tense, or wired at night.
Your body may be missing the support it needs — and your genes can tell you where to start.
🧬 Get your genetic test here
🧬 Or book a 1:1 consultation to review your results